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| 발행년 : | 2014 |
|---|---|
| 구분 : | 국내학술지 |
| 학술지명 : | 인구의학연구논집 |
| 관련링크 : | http://www.riss.kr/link?id=A100246014 |
임상등급 인간 배아줄기세포주 확립 연구 동향
= An Overview for the Establishment of Clinical Grade Human Embryonic
제어번호 100246014
저자명 설혜원 ( Hye Won Seol ) ,오선경 ( Sun Kyung Oh ) ,최영민 ( Young Min Choi )
학술지명 人口醫學硏究論集
권호사항 Vol.27 No.- [2014]
발행처 서울대학교 인구의학연구소
자료유형 학술저널
수록면 1-8(8쪽)
언어 Korean
발행년도 2014년
판매처 한국학술정보
초록
The pluripotency of human embryonic stem cells(hESC5) makes them very attractive as a source of various cell types that could be used therapeurtically in regenerative. Many hESC lines have been established for over the last several years. However, most of them were generated in the presence of animal serum and animal derived feeder cells. Therefore, eliminating all sources of contamination, both animal-derived and human cell-derived, during hESC derivation and propagarion is necessary before hESC derivatives can be used clinically. The long-term success ofr good manufacruring practices (GMP) compliance depends critically on maintaining and implementing a stringent quality control system which is also dictated by the regulatory authorities in different countries. GMP-qualitry xeno-freen hESC lines could be currently established using embryos cultured in a GMP facility, isolating the inner cell mass mechanically, deriving lines on human feeders originally cultured in xeno-free medium in a GMP laboratory, and using xeno-free media for derivation and culture on hESC lines themselves, In this paper, we reviewed the current studies for establishmenr of the clinical-grade hESC lines.
주제어
Clinical ,Grade human embryonic stem cell derivation ,culture
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