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lib@nibp.kr
글 수 4,668
| 발행년 : | 2014 |
|---|---|
| 구분 : | 학위논문 |
| 학술지명 : | |
| 관련링크 : | http://www.riss.kr/link?id=T13525273 |
Rh Blood Group Conversion using Engineered Nucleases = 유전자 가위를 이용한 Rh 혈액형 변환
- 저자
김영훈
- 형태사항
iv, 44 p. : 삽도 ; 26 cm.
- 일반주기
지도교수: 김형범
권두 Astract, 권말 국문요지 수록
참고문헌: p. 33-41 - 학위논문사항
학위논문(석사)-- 한양대학교 의생명공학전문대학원 : 의생명과학과 2014. 8
- 발행국
서울
- 언어
영어
- 출판년
2014
초록 (Abstract)
- The Rh (Rhesus) blood group system (including the Rh factor) is the most important blood group system following ABO blood group. The Rh blood group system consists of mainly five antigens D, C, c, E, and e. The commonly used terms Rh factor, Rh positive and Rh negative refer to the D antigen only. In this study, we used TALENs (transcription activator-like effector nucleases), a powerful tool for genome editing on HiDEP-1 (human iPS cell-derived erythroid progenitor-1) cell line for the conversion of Rh positive patient cell line to Rh negative HiDEP-1 cell line. Additionally, we confirmed Rh negative HiDEP-1 cell line can differentiate into erythrocyte which does not express D antigen. Here, we established a technology to convert human blood groups using engineered nucleases. In addition, this technology could be further utilized for blood transfusion medicine.
목차 (Table of Contents)
- CONTENTS
- CONTENTS ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••ⅰ
- LIST OF FIGURES ••••••••••••••••••••••••••••••••••••••••••••••••••••••••ii
- ABSTRACT •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••iv
- I. INTRODUCTION•••••••••••••••••••••••••••••••••••••••••••••••••••••••••1
- II. MATERIALS AND METHODS ••••••••••••••••••••••••••••••••••••••5
- III. RESULTS•••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••10
- IV. DISCUSSION• ••••••••••••••••••••••••••••••••••••••••••••••••••••••••30
- V. REFERENCES•••••••••••••••••••••••••••••••••••••••••••••••••••••••••33
- VI. ABSTRACT IN KOREAN•••••••••••••••••••••••••••••••••••••••••••42
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