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새로운 유전체 편집용 유전자 가위, 크리스퍼 (CRISPR/Cas9 system) / 권순일

15 유전학 조회 수 390 추천 수 0 2018.06.15 14:58:43

도서관2 *.223.3.98 https://www.nibp.kr/xe/info4_3/119519

발행년 :	2015
구분 :	국내학술지
학술지명 :	한국고등직업교육학회논문집
관련링크 :	http://www.riss.kr/link?id=A103621894

새로운 유전체 편집용 유전자 가위, 크리스퍼 (CRISPR/Cas9 system)

= A new genome-editing genetic scissors, CRISPR/Cas9 system - opening a new era of molecular biology ? -

저자[authors] 권순일(Sun-Il Kwon)
학술지명[periodical name] 한국고등직업교육학회논문집
권호사항[Volume/Issue] Vol.16No.1·2[2015]
발행처[publisher] 한국고등직업교육학회
자료유형[Document Type] 학술저널
수록면[Pagination] 61-71
언어[language] Korean
발행년[Publication Year] 2015
주제어[descriptor] genome-editing,CRISPR/Cas9,TALENs,zinc finger nucleases,guide RNA

초록[abstracts]

[The emergence of a new genome-editing tool called CRISPR/Cas9 system which makes accurate and targeted modification to the genome of living organisms has drawn keen interest from world biomedical researchers. The CRISPR/Cas9 system is based on a prokaryotic immune system which gives acquired immunity to invading exogenous genetic elements by recognizing the memorized DNA sequences. The previous versions of genome-editing tools, zinc finger nucleases and TALENs, are costly and time-consuming to prepare, because they rely on protein engineering to target specific sites in the genome. However, the CRISPR/Cas9 system can recognize target sites on the basis of nucleotide base pairing with a short sequence of guide RNA. thus make it easier and flexible to implement. The CRISPR/Cas9 system could be used for editing/modifying the endogenous genome, disrupting the gene of interest, activating or repressing gene expression and labeling a regions of genomic DNA for imaging in a wide variety of biomedically important cell types and organisms. Due to these abilities, CRISPR/Cas9 system will transform genomic research and will spur the opening of a new era of molecular biomedicine and agricultural breeding. In this article, the latest research trend and applications of CRISPR/Cas9 system were studied. The ethical concern of CRISPR/Cas9 on human therapeutic use were also discussed.]

목차[Table of content]

Abstract Ⅰ. 서론 Ⅱ. 유전자 가위의 개발 Ⅲ. 크리스퍼 기술의 적용 확산과 제한 Ⅳ. 크리스퍼의 적용 분야 V. 논의 참고문헌

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