인간 전분화능줄기세포에서 유전자 편집 기술의 연구 동향 = Current Trends of Genome Editing Methods in Human Pluripotent Stem Cells

• 제어번호 : 100246019
• 저자명 : 정주원 ( Juwon Jung ) ,오선경 ( Sun Kyung Oh ) ,최영민 ( Young Min Choi )
• 학술지명 : 人口醫學硏究論集
• 권호사항 : Vol.27 No.- [2014]
• 발행처 : 서울대학교 인구의학연구소
• 자료유형 : 학술저널
• 수록면 : 38-45(8쪽)
• 언어 : Korean
• 발행년도 : 2014년
• 주제어 : Genome editing ZFN ,TALEN ,CRISPR/CAS9

초록 (Abstract)

Human pluripotent stem cells(hPSCs) are useful resource for cell replacement therapy and modeling of human diseases. Recently, genome editing technologies have has been applied in hPSCs that are rapidly developed for targeted gene function of the human genome. These technologies including zinc finger nucleases(ZFNs), transcription activator like effector nucleases (TALENs) and clustered regulary interspaced short palindromic repeat(CRISPR)/CRISPR associated protein 9(CAS9) RNA guided nucleases are genetically modified tools which have potentials for diverse biolohical research fields. In this review, we discussed an overview of genome editing merhods and understanding their characters and drawback of this manipulation.