줄기세포로부터 퇴행성 황반변성 치료를 위한 망막색소상피의 생선 연구 동향
= Generation of Retinal Pigment Epithelium from Stem Cells for Treatment of Age-related Macular Degeneration

 
제어번호 101669433
저자명 유대훈 ( Dae Hoon Yoo )  , 지소연 ( So Yeon Ji )  , 조명수 ( Myung-soo Cho ) 
학술지명 人口醫學硏究論集
권호사항 Vol.28 No.- [2015] 
발행처 서울대학교 인구의학연구소 
자료유형 학술저널
수록면 40-50(11쪽)
언어 Korean
발행년도 2015년
판매처 한국학술정보

 
초록
Age-related macular degeneration (AMD) is characterized by the loss or dysfunction of retinal pigment epithelium (RPE) and one of the major causes of irreversible blindness in the elderly. According to the presence or absence of choroidal neovascu -larization, advanced AMD can be classified into two types (dry AMD and wet AMD). Currenrly, no treatments can reverse dry AMD, regardless of the fact that dietary supplementation with defined vitamins and antioxidants has been shown to alleviate progression. Therefore, RPE replacement represents potential new approaches for dry AMD. Functional RPE cells could be generated from stem cells by spontaneous differentiation, coculture, treatment of the defined factors, or cell reprogramming. In this review, we summarize molecular and structural characteristics of RPE cells and discuss RPE-impairment, RPE-related diseases that will be amenable to cell replacement strategies and several stem cell sources to produce RPE in vitro.

주제어
age-related macular degeneration  , human pluripotent stem cell  , retinal pigment epithelium