원저 : 생체 신장 제공자의 수술 후 장기 추적 결과 = Original Articles : Long Term Outcomes for Living Renal Donors

• 제어번호 : 60026400
• 저자명 : 이호균 ( Ho Kyun Lee ) ,박종훈 ( Jong Hun Park ) ,정상영 ( Sang Young Chung ) ,최수진나 ( Soo Jin Na Choi )
• 학술지명 : 大韓移植學會誌(The Journal of the Korean Transplantation Society)
• 권호사항 : Vol.26 No.1 [2012]
• 발행처 : 대한이식학회
• 발행처 URL : http://www.ksot.org
• 자료유형 : 학술저널
• 수록면 : 10-14(5쪽)
• 언어 : Korean
• 발행년도 : 2012년
• KDC : 514.2605
• 주제어 : 신장 이식 ,생체기증자 ,안정성 ,Kidney transplantation ,Living donors ,Safety

초록 (Abstract)

Background: Kidney donation is a relatively safe procedure with minimal adverse effects. But some reports have described the development of proteinuria and hypertension in donors after nephrectomy. There have been a number of non-Korean studies which conclude that the procedure is relatively safe and a good quality of life is expected for living donors after kidney transplantation, but not enough of these studies have been published in Korea. We evaluated the physiologic and psychosocial impacts after kidney donation in this study. Methods: Between April 1988 and April 2010, we performed 201 living donor nephrectomies and obtained information for 88 (43.7%) of the donors. We measured their estimated glomerular filtration rate (GFR), blood pressure, body mass index, hemoglobin and cholesterol level, and assessed the prevalence of hypertension and proteinuria in this group. These donors completed a questionnaire regarding their health status and psychosocial outcomes after donation. Results: The average time of the donor assessment after nephrectomy was 95.05±85.45 months (range, 6∼261). The left kidney was used in 76 patients (86%). There was a total complication rate of 8%, but no serious complications were observed. Proteinuria was found in 9 patients (10%) and hypertension in 11 patients (11%). GFR decreased from 103.65±25.02 mL/min to 76.12±19.90 mL/min ( P＜0.001) and hemoglobin decreased from 13.91±1.62 g/dL to 13.01±1.72 g/dL ( P＜0.001). Five patients (6%) developed a post-donation GFR between 40 and 60 mL/min, with 2 patients being observed to have a post-donation GFR below 20 mL/min. In the questionnaire responses, most donors did not report problems affecting routine life or any economic impact. Their donation satisfaction results were very high (92%). Conclusions: Living kidney donors were observed to result in reduced GFR after nephrectomy. Follow-up visits with living kidney donors is essential in order to monitor risk factors related to the deterioration of their residual kidney function.