뇌사자신장이식에서 KONOS의 경계공여자 기준의 개선을 위한 다기관 연구 수행의 타당성을 평가하기 위한 예비연구
= A Preliminary Study to Revise the Marginal Donor Criteria of KONOS in Deceased Donor Kidney Transplantation
- 저자[authors] 허우성 ( Wooseong Huh )
- 학술지명[periodical name] 大韓移植學會誌
- 권호사항[Volume/Issue] Vol.31No.2[2017]
- 발행처[publisher] 대한이식학회
- 자료유형[Document Type] 학술저널
- 수록면[Pagination] 59-67
- 언어[language] Korean
- 발행년[Publication Year] 2017
- 주제어[descriptor] Organ donor, Brain death, Kidney transplantation, 장기기증자, 뇌사, 신장이식
초록[abstracts]
[Background: The Korean Network for Organ Sharing (KONOS), which was established in December 31st, 1999, is a nationwide system of deceased donor detection and distribution. From its inception, KONOS has defined marginal donors and used this definition for over 15 years. However, this definition should be reevaluated to determine if it requires revision. This study was conducted to confirm the feasibility of the main study for revision of the marginal donor definition in deceased donor kidney transplantation. Methods: This study is a retrospective meta-analysis of 786 patients who had deceased donor kidney transplant from six centers. After the data validation process, multivariable analysis was conducted to evaluate whether the marginal donor criteria of KONOS or UNOS expected adequately in terms of graft survival and delayed graft function (DGF). Results: Neither the KONOS or UNOS criteria affected graft survival. Expanded criteria for donors of UNOS was a risk factor for DGF. However, KONOS criteria did not affect DGF. Conclusions: Based on this preliminary study, there is a need to conduct a study to revise the marginal donor criteria of KONOS in deceased donor kidney transplantation. Such a study should have large scale and long-term follow-up data.]