발행년 : | 2014 |
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구분 : | 국내학술지 |
학술지명 : | 인구의학연구논집 Vol.27 |
관련링크 : | http://www.riss.kr/link?id=A100246019 |
인간 전분화능줄기세포에서 유전자 편집 기술의 연구 동향 = Current Trends of Genome Editing Methods in Human Pluripotent Stem Cells
초록 (Abstract)
Human pluripotent stem cells(hPSCs) are useful resource for cell replacement therapy and modeling of human diseases. Recently, genome editing technologies have has been applied in hPSCs that are rapidly developed for targeted gene function of the human genome. These technologies including zinc finger nucleases(ZFNs), transcription activator like effector nucleases (TALENs) and clustered regulary interspaced short palindromic repeat(CRISPR)/CRISPR associated protein 9(CAS9) RNA guided nucleases are genetically modified tools which have potentials for diverse biolohical research fields. In this review, we discussed an overview of genome editing merhods and understanding their characters and drawback of this manipulation.